TMEM123

Across TCGA patient cohorts, TMEM123 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM123-associated genes across cancer lineages are TRAJ9, TRAJ43, and RN7SL625P. Each is linked with TMEM123 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM123-to-partner and partner-to-TMEM123 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ9 grouped by TMEM123-low versus TMEM123-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM123→partner) and Y-score (partner→TMEM123) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ9 →	+1.224	+3.033	<.001	.004	3	2
BLCA	TRAJ43 →	+0.735	+4.588	<.001	.008	3	2
UCEC	RN7SL625P →	+0.339	+3.939	<.001	<.001	3	1
UCEC	SNORD91B →	+0.799	+3.605	<.001	.004	3	1
UCEC	LSP1P3 →	+0.421	+3.385	<.001	.001	3	1
BLCA	RN7SL260P →	+0.162	+5.018	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

TRAJ9 by TMEM123 expression — UCEC

Explore this box plot interactively →