TMEM121B

Across TCGA patient cohorts, TMEM121B RNA expression is significantly associated with the protein abundance of many other proteins, with 11,617 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM121B-associated proteins across cancer lineages are ARHGAP4, TIAM1_S231, and SAMHD1_T592. Each is linked with TMEM121B in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM121B-to-partner and partner-to-TMEM121B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM121B versus ARHGAP4 in CCRCC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121B→partner) and Y-score (partner→TMEM121B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ARHGAP4 →	+0.412	+0.256	<.001	.001	3	4
CCRCC	TIAM1_S231 →	+0.764	+0.413	<.001	<.001	3	4
HNSC	SAMHD1_T592 →	+0.581	+0.263	.001	.009	3	4
HNSC	PHLDB1_S404 →	+0.526	+0.280	<.001	.001	3	3
HNSC	PIK3AP1_S642 →	+0.557	+0.229	<.001	<.001	3	3
CCRCC	ARHGAP9_S475 →	+0.517	+0.362	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,617 associations by consensus.

TMEM121B vs ARHGAP4 — CCRCC

Explore this scatter interactively →