TMEM121B

Across TCGA patient cohorts, TMEM121B protein abundance is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMEM121B-associated genes across cancer lineages are SLC35A2, PYY, and CDK15. Each is linked with TMEM121B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM121B-to-partner and partner-to-TMEM121B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM121B versus SLC35A2 in GBM, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121B→partner) and Y-score (partner→TMEM121B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC35A2 →	+0.414	+0.672	.003	.007	3	1
GBM	PYY →	+0.346	+0.730	.005	.002	3	1
GBM	CDK15 →	-0.338	-0.640	<.001	.007	3	1
GBM	DLGAP1 →	-2.105	-0.792	.001	.002	3	1
GBM	CCNYL2 →	-0.637	-0.548	<.001	.001	3	1
GBM	LINC00839 →	-2.225	-0.766	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

TMEM121B vs SLC35A2 — GBM

Explore this scatter interactively →