TMEM121B

Across TCGA cell cohorts, TMEM121B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM121B-associated GO terms across cancer lineages are Positive regulation of DNA repair, Positive regulation of double-strand break repair, and Positive regulation of DNA metabolic process. Each is linked with TMEM121B in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM121B-to-partner and partner-to-TMEM121B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by TMEM121B-low versus TMEM121B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM121B→partner) and Y-score (partner→TMEM121B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA repair →	+0.086	+1.079	<.001	<.001	3	11
BONE	Positive regulation of double-strand break repair →	+0.086	+0.843	<.001	<.001	3	10
BONE	Positive regulation of DNA metabolic process →	+0.089	+0.905	<.001	<.001	3	10
BONE	Positive regulation of monoatomic ion transport →	-0.109	-0.994	<.001	<.001	3	10
LUNG_SCLC	Nucleosome organization →	+0.124	+1.362	<.001	.003	3	9
BONE	Regulation of DNA recombination →	+0.093	+1.097	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Positive regulation of DNA repair by TMEM121B expression — BONE

Explore this box plot interactively →