Across TCGA pan-cancer cohorts, TMEM120A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TMEM120A data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TMEM120A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TMEM120A expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where TMEM120A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.658	0.406	.035	4	view →
CCRCC	OS	Median	All	0.730	1.000	.023	4	view →
HNSC	OS	Median	II,III,IV	0.825	0.643	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TMEM120A tumor-vs-normal RNA expression · all TMEM120A data types