Across TCGA pan-cancer cohorts, TMEM120A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TMEM120A’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where TMEM120A RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM120A is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.
COAD, KIRC, and KICH are the cancer types where TMEM120A tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM120A RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.