Across TCGA patient cohorts, TMEM120A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM120A-associated genes across cancer lineages are eIF4G, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with TMEM120A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM120A-to-partner and partner-to-TMEM120A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM120A→partner) and Y-score (partner→TMEM120A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.359	+2.700	.010	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-2.000	.039	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.175	-1.986	.021	.032	3	1
UCEC	mTOR_pS2448 →	-0.158	-3.150	.018	.019	3	1
UCEC	P-Cadherin →	-0.139	-2.999	.032	.035	3	1
UCEC	Smad3 →	+0.151	+2.999	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TMEM120A survival (RNA) · tumor vs normal (RNA) · all TMEM120A data types