Across TCGA pan-cancer cohorts, TMEM119 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TMEM119 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM119 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM119 expression acts as an unfavorable survival marker.

COAD and UCEC are the cancer types where TMEM119 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.237	0.696	.021	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TMEM119 tumor-vs-normal RNA expression · all TMEM119 data types