Across TCGA pan-cancer cohorts, TMEM119 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TMEM119’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where TMEM119 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM119 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, KICH, and LIHC are the cancer types where TMEM119 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM119 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.