Across TCGA patient cohorts, TMEM119 mutation is significantly associated with the RNA expression of many other genes, with 928 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TMEM119-associated genes across cancer lineages are OR9I3P, PLS3-AS1, and ANKRD20A3P. Each is linked with TMEM119 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM119-to-partner and partner-to-TMEM119 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM119→partner) and Y-score (partner→TMEM119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR9I3P →	+0.135	+5.251	<.001	.006	3	3
UCEC	PLS3-AS1 →	+0.249	+3.288	.008	.008	3	2
SKCM	ANKRD20A3P →	+0.004	+1.933	<.001	.007	3	2
SKCM	DHRS11 →	+0.600	+2.434	.001	.001	3	2
UCEC	CLDND2 →	+0.934	+3.595	<.001	.001	3	2
UCEC	COMTD1 →	+0.977	+3.470	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 928 associations by consensus.

Exploration

TMEM119 survival (RNA) · tumor vs normal (RNA) · all TMEM119 data types