Across TCGA patient cohorts, TMEM119 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM119-associated genes across cancer lineages are RAD51, c-Met_pY1235, and IGFBP2. Each is linked with TMEM119 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM119-to-partner and partner-to-TMEM119 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM119→partner) and Y-score (partner→TMEM119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.286	+3.000	<.001	.036	3	1
UCEC	c-Met_pY1235 →	+0.095	+3.009	.019	.019	3	1
SKCM	IGFBP2 →	-0.515	-3.321	.029	.009	3	1
SKCM	4E-BP1_pT70 →	+0.165	+1.891	.048	.030	3	1
UCEC	ERK2 →	+0.358	+3.169	<.001	.019	2	1
UCEC	ATM →	-0.813	-3.169	.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TMEM119 survival (RNA) · tumor vs normal (RNA) · all TMEM119 data types