Across TCGA cell cohorts, TMEM119 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,925 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMEM119-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of tumor necrosis factor-mediated signaling pathway. Each is linked with TMEM119 in more than 6 cancer types. Because this analysis shows association rather than direction, both TMEM119-to-partner and partner-to-TMEM119 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM119→partner) and Y-score (partner→TMEM119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of myoblast fusion →	+0.093	+0.050	.005	.008	3	7
BLOOD_Lymphoma	Negative regulation of syncytium formation by plasma membrane fusion →	+0.064	+0.286	<.001	.004	3	6
PANCREAS	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.073	+0.049	<.001	.001	3	6
LARGE_INTESTINE	Regulation of cell-substrate junction organization →	+0.048	+0.057	.002	.004	3	6
PANCREAS	Negative regulation of calcium ion export across plasma membrane →	+0.044	+0.046	.005	.009	3	5
SOFT_TISSUE	Positive regulation of epithelial cell migration →	+0.061	+2.060	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,925 associations by consensus.

Exploration

TMEM119 survival (RNA) · tumor vs normal (RNA) · all TMEM119 data types