Across TCGA cell cohorts, TMEM119 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM119-associated genes across cancer lineages are ADAM7, MAJIN, and RBMY1J. Each is linked with TMEM119 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM119-to-partner and partner-to-TMEM119 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM119→partner) and Y-score (partner→TMEM119) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	2
LARGE_INTESTINE	MAJIN →	+0.113	+3.554	<.001	.007	3	1
LARGE_INTESTINE	RBMY1J →	+0.006	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ELOA3CP →	+0.145	+3.509	<.001	.008	3	1
LARGE_INTESTINE	OOSP4A →	+0.140	+4.115	<.001	.001	3	1
SKIN	KRTAP2-2 →	+0.049	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TMEM119 survival (RNA) · tumor vs normal (RNA) · all TMEM119 data types