TMEM117

Across TCGA cell cohorts, TMEM117 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,580 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM117-associated GO terms across cancer lineages are Protein demannosylation, Protein alpha-1,2-demannosylation, and Skeletal myofibril assembly. Each is linked with TMEM117 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMEM117-to-partner and partner-to-TMEM117 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein demannosylation grouped by TMEM117-low versus TMEM117-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM117→partner) and Y-score (partner→TMEM117) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein demannosylation →	+0.125	+0.902	.003	.002	3	9
URINARY_TRACT	Protein alpha-1,2-demannosylation →	+0.125	+0.902	.003	.002	3	9
BLOOD_Leukemia	Skeletal myofibril assembly →	-0.655	-0.653	<.001	.001	3	8
LIVER	Nuclear body organization →	-0.154	-2.122	<.001	<.001	3	8
LIVER	PML body organization →	-0.279	-1.787	<.001	<.001	3	8
LUNG_NSCLC_LUSC	C-terminal protein lipidation →	-0.246	-1.218	.006	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,580 associations by consensus.

Protein demannosylation by TMEM117 expression — URINARY_TRACT

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