TMEM117

Across TCGA cell cohorts, TMEM117 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMEM117-associated genes across cancer lineages are CFHR4, OR1A2, and RESP18. Each is linked with TMEM117 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM117-to-partner and partner-to-TMEM117 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR4 grouped by TMEM117-low versus TMEM117-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM117→partner) and Y-score (partner→TMEM117) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CFHR4 →	+0.132	+3.866	.001	.006	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	RESP18 →	+0.028	+3.947	<.001	.004	3	1
LARGE_INTESTINE	PRDM7 →	+0.126	+3.302	.008	.008	3	1
LARGE_INTESTINE	GPR171 →	+0.011	+3.009	.003	.001	3	1
LARGE_INTESTINE	MBD3L3 →	+0.078	+3.415	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CFHR4 by TMEM117 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →