TMEM114

Across TCGA patient cohorts, TMEM114 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,948 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TMEM114-associated GO terms across cancer lineages are Vascular associated smooth muscle cell development, Negative regulation of hemopoiesis, and Negative regulation of growth. Each is linked with TMEM114 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMEM114-to-partner and partner-to-TMEM114 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vascular associated smooth muscle cell development grouped by TMEM114-low versus TMEM114-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM114→partner) and Y-score (partner→TMEM114) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Vascular associated smooth muscle cell development →	+0.089	+0.224	<.001	<.001	3	13
STAD	Negative regulation of hemopoiesis →	+0.040	+0.157	<.001	<.001	3	12
STAD	Negative regulation of growth →	+0.051	+0.179	<.001	<.001	3	12
STAD	Positive regulation of release of cytochrome c from mitochondria →	+0.060	+0.144	<.001	<.001	3	12
STAD	Collagen metabolic process →	+0.053	+0.170	<.001	<.001	3	12
STAD	Collagen biosynthetic process →	+0.062	+0.173	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,948 associations by consensus.

Vascular associated smooth muscle cell development by TMEM114 expression — STAD

Explore this box plot interactively →