TMEM114

Across TCGA pan-cancer cohorts, TMEM114 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TMEM114 data layer compared with 1 for mutation status.

The strongest signal is observed in thymoma (THYM), where higher TMEM114 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TMEM114 expression acts as an unfavorable survival marker, although some lineages such as UCEC and MESO show a favorable association.

THYM, UCEC, and MESO are the cancer types where TMEM114 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	II,III,IV	0.753	0.927	.002	93	view →
UCEC	DFS	Median	All	0.717	0.571	<.001	78	view →
MESO	DFS	Tertile	All	0.508	0.277	<.001	73	view →
HNSC	DFS	Tertile	III,IV	0.441	0.302	.003	46	view →
LGG	OS	Quartile	All	0.707	0.850	<.001	37	view →
COAD	OS	Median	III,IV	0.592	0.798	.009	32	view →
UCS	OS	Tertile	IV	0.156	0.781	.024	30	view →
READ	OS	Quartile	IV	0.675	0.975	.008	22	view →
ACC	DFS	Tertile	IV	0.599	0.237	.045	15	view →
OV	OS	Quartile	II,III,IV	0.260	0.348	.010	14	view →
UVM	OS	Tertile	All	1.000	0.524	.019	12	view →
BRCA	DFS	Quartile	All	0.187	1.000	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TMEM114–THYM (DFS)

Open the THYM breakdown →