TMEM109

Across TCGA patient cohorts, TMEM109 mutation is significantly associated with the RNA expression of many other genes, with 3,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM109-associated genes across cancer lineages are RPS12P15, RN7SL248P, and RNU6-718P. Each is linked with TMEM109 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM109-to-partner and partner-to-TMEM109 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS12P15 grouped by TMEM109-low versus TMEM109-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM109→partner) and Y-score (partner→TMEM109) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPS12P15 →	+0.173	+4.693	<.001	.007	3	2
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	2
UCEC	RNU6-718P →	+0.104	+3.069	.004	.005	3	2
CESC	RPL31P45 →	+0.093	+5.201	<.001	.007	3	2
CESC	RN7SL62P →	+0.139	+5.812	<.001	.003	3	1
CESC	TPT1P11 →	+0.083	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,299 associations by consensus.

RPS12P15 by TMEM109 expression — COAD

Explore this box plot interactively →