TMEM108

Across TCGA patient cohorts, TMEM108 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM108-associated genes across cancer lineages are EGFR_pY1068, ERK2, and p62 Lck ligand. Each is linked with TMEM108 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMEM108-to-partner and partner-to-TMEM108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM108-low versus TMEM108-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM108→partner) and Y-score (partner→TMEM108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.241	-2.459	.014	.018	3	2
UCEC	ERK2 →	+0.178	+3.169	.018	.018	3	2
UCEC	p62 Lck ligand →	+0.300	+1.584	.019	.036	3	2
COAD	PCNA →	+0.316	+2.815	.020	.036	1	3
COAD	Caspase-7-cleavedD198 →	+1.722	+2.815	<.001	.036	1	3
UCEC	Heregulin →	-0.130	-3.156	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

EGFR_pY1068 by TMEM108 expression — UCEC

Explore this box plot interactively →