TMEM108

Across TCGA pan-cancer cohorts, TMEM108 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEM108’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TMEM108 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM108 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LIHC are the cancer types where TMEM108 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM108 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	−1.686	<.001	9	view →
COAD	Male	II,III,IV	−0.435	<.001	9	view →
LIHC	Female	All	+0.137	<.001	8	view →
LUAD	Male	All	−0.905	<.001	7	view →
THCA	Female	II,III,IV	+1.603	<.001	6	view →
LUSC	Male	II,III,IV	−1.296	<.001	6	view →
READ	All	All	−0.575	<.001	5	view →
STAD	All	All	−0.479	.008	4	view →
KIRP	Female	All	−0.388	.002	4	view →
PRAD	All	All	−0.608	<.001	2	view →
BRCA	All	All	−0.188	.042	2	view →
CHOL	All	All	+0.159	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEM108–BLCA

Open the BLCA breakdown →