TMEM108

Across TCGA cell cohorts, TMEM108 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,672 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM108-associated GO terms across cancer lineages are Cellular response to brain-derived neurotrophic factor stimulus, Protein-RNA complex assembly, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with TMEM108 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMEM108-to-partner and partner-to-TMEM108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to brain-derived neurotrophic factor stimulus grouped by TMEM108-low versus TMEM108-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM108→partner) and Y-score (partner→TMEM108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to brain-derived neurotrophic factor stimulus →	-0.296	-1.074	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Protein-RNA complex assembly →	+0.064	+0.610	<.001	.002	3	9
SOFT_TISSUE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.066	+1.194	<.001	.006	3	9
LUNG_NSCLC_LUSC	Cytoplasmic translation →	+0.073	+1.002	.002	.003	2	10
SOFT_TISSUE	Transcription initiation at RNA polymerase II promoter →	+0.048	+1.566	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Ribonucleoside triphosphate biosynthetic process →	+0.063	+0.407	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,672 associations by consensus.

Cellular response to brain-derived neurotrophic factor stimulus by TMEM108 expression — BONE

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