TMEM108

Across TCGA cell cohorts, TMEM108 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM108-associated genes across cancer lineages are SPINK9, RBP2, and AWAT2. Each is linked with TMEM108 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM108-to-partner and partner-to-TMEM108 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINK9 grouped by TMEM108-low versus TMEM108-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM108→partner) and Y-score (partner→TMEM108) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPINK9 →	+0.329	+3.793	<.001	.007	3	1
BLOOD_Leukemia	RBP2 →	+0.040	+4.037	.002	.004	3	1
BLOOD_Leukemia	AWAT2 →	+0.012	+3.705	<.001	.007	3	1
BLOOD_Leukemia	INSM2 →	+0.321	+3.769	<.001	.008	3	1
BLOOD_Leukemia	IQCF1 →	+0.115	+3.769	<.001	.008	3	1
BLOOD_Leukemia	SIX6 →	+2.206	+3.769	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SPINK9 by TMEM108 expression — LARGE_INTESTINE

Explore this box plot interactively →