TMEM108-AS1

Across TCGA pan-cancer cohorts, TMEM108-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM108-AS1 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TMEM108-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM108-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

BRCA, COAD, and HNSC are the cancer types where TMEM108-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	IV	0.106	0.791	<.001	36	view →
COAD	OS	Tertile	IV	0.183	0.670	.003	36	view →
HNSC	DFS	Tertile	III,IV	0.328	0.554	.010	36	view →
DLBC	DFS	Tertile	IV	0.128	1.000	.017	28	view →
ACC	DFS	Tertile	III,IV	0.216	0.523	.029	27	view →
TGCT	OS	Median	All	0.885	1.000	.010	18	view →
BLCA	DFS	Tertile	IV	0.083	0.264	.012	18	view →
LUSC	OS	Tertile	III,IV	0.165	0.747	.005	18	view →
LIHC	OS	Tertile	III,IV	0.331	0.662	.019	18	view →
KIRC	DFS	Tertile	All	0.481	0.666	.020	17	view →
MESO	OS	Tertile	IV	0.286	0.727	.022	15	view →
LUAD	DFS	Median	All	0.845	0.711	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM108-AS1–BRCA (OS)

Open the BRCA breakdown →