TMEM108-AS1

Across TCGA pan-cancer cohorts, TMEM108-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMEM108-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where TMEM108-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM108-AS1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where TMEM108-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM108-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.208	<.001	7	view →
LUSC	All	All	−0.119	<.001	6	view →
LUAD	Female	II,III,IV	−0.112	.003	3	view →
STAD	All	All	−0.018	.011	2	view →
BRCA	All	All	+0.069	.049	1	view →
KIRC	All	All	+0.003	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMEM108-AS1–THCA

Open the THCA breakdown →