TMEM107

Across TCGA patient cohorts, TMEM107 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM107-associated genes across cancer lineages are ATM, EGFR, and eIF4E. Each is linked with TMEM107 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM107-to-partner and partner-to-TMEM107 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TMEM107-low versus TMEM107-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM107→partner) and Y-score (partner→TMEM107) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.571	-2.459	.009	.020	3	2
UCEC	EGFR →	-0.197	-3.000	.010	.036	3	1
UCEC	eIF4E →	+0.223	+2.459	.029	.020	3	1
UCEC	MSH2 →	-0.333	-2.973	.002	.035	3	1
UCEC	Notch1 →	+0.220	+3.179	.001	.010	3	1
UCEC	Annexin-1 →	+0.667	+3.019	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by TMEM107 expression — UCEC

Explore this box plot interactively →