TMEM107

Across TCGA pan-cancer cohorts, TMEM107 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM107’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TMEM107 RNA is repressed in tumor relative to normal tissue. In most cancer types TMEM107 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, BLCA, and LIHC are the cancer types where TMEM107 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM107 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.941	<.001	10	view →
BLCA	All	III,IV	+0.846	<.001	9	view →
LIHC	Female	All	+0.652	<.001	8	view →
COAD	All	All	+0.385	.001	7	view →
HNSC	Male	All	+0.562	<.001	6	view →
CHOL	Male	All	+1.895	<.001	5	view →
LUSC	All	III,IV	−0.971	<.001	4	view →
LUAD	Female	II,III,IV	−0.528	<.001	4	view →
KIRP	All	All	+0.424	.003	4	view →
THCA	Male	III,IV	−0.379	.006	4	view →
KIRC	All	All	+0.255	<.001	3	view →
PRAD	All	All	−0.392	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM107–KICH

Open the KICH breakdown →