TMEM106C

Across TCGA patient cohorts, TMEM106C RNA expression is significantly associated with the protein abundance of many other proteins, with 17,177 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TMEM106C-associated proteins across cancer lineages are RFC1_T506, RRM2, and BRIP1_T989. Each is linked with TMEM106C in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM106C-to-partner and partner-to-TMEM106C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM106C versus RFC1_T506 in LUAD, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106C→partner) and Y-score (partner→TMEM106C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RFC1_T506 →	+1.008	+0.575	<.001	<.001	3	6
GBM	RRM2 →	+0.761	+0.630	<.001	<.001	3	6
PDAC	BRIP1_T989 →	+1.038	+0.769	.008	.009	3	6
GBM	DCTPP1 →	+0.456	+0.647	<.001	<.001	3	6
UCEC	DTL_S478 →	+0.868	+0.875	<.001	.002	3	6
LUAD	MCM2_S41 →	+0.723	+0.706	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,177 associations by consensus.

TMEM106C vs RFC1_T506 — LUAD

Explore this scatter interactively →