TMEM106C

Across TCGA patient cohorts, TMEM106C mutation is significantly associated with the RNA expression of many other genes, with 393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM106C-associated genes across cancer lineages are TTTY6, MIR383, and RNU6-289P. Each is linked with TMEM106C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106C-to-partner and partner-to-TMEM106C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY6 grouped by TMEM106C-low versus TMEM106C-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106C→partner) and Y-score (partner→TMEM106C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTTY6 →	+0.089	+7.930	<.001	.008	3	1
LUAD	MIR383 →	+0.306	+7.930	<.001	.008	3	1
LUAD	RNU6-289P →	+0.334	+7.930	<.001	.008	3	1
LUAD	RNU6-692P →	+0.332	+7.930	<.001	.008	3	1
LUAD	MTATP6P30 →	+0.064	+7.930	<.001	.008	3	1
LUAD	TSPY4 →	+0.014	+7.930	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 393 associations by consensus.

TTTY6 by TMEM106C expression — LUAD

Explore this box plot interactively →