TMEM106C

Across TCGA patient cohorts, TMEM106C mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM106C-associated genes across cancer lineages are EGFR_pY1068, p27_pT198, and Tuberin. Each is linked with TMEM106C in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106C-to-partner and partner-to-TMEM106C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM106C-low versus TMEM106C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106C→partner) and Y-score (partner→TMEM106C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-2.459	.023	.020	3	1
UCEC	p27_pT198 →	+0.129	+3.000	.012	.036	3	1
UCEC	Tuberin →	+0.260	+2.817	.046	.036	3	1
UCEC	PCNA →	+0.270	+3.169	.009	.019	2	1
UCEC	p62 Lck ligand →	+0.582	+3.584	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

EGFR_pY1068 by TMEM106C expression — UCEC

Explore this box plot interactively →