TMEM106B

Across TCGA patient cohorts, TMEM106B RNA expression is significantly associated with the protein abundance of many other proteins, with 15,172 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMEM106B-associated proteins across cancer lineages are NUDCD3, CD48, and EHBP1L1_S191. Each is linked with TMEM106B in more than 5 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM106B versus NUDCD3 in LUAD, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NUDCD3 →	+0.326	+0.478	<.001	<.001	3	6
BRCA	CD48 →	-0.857	-0.708	<.001	.003	3	5
HNSC	EHBP1L1_S191 →	-0.530	-0.520	<.001	.005	3	5
BRCA	ISG20 →	-0.868	-0.759	<.001	<.001	3	5
BRCA	ANKMY2 →	+0.353	+0.687	<.001	<.001	3	5
LSCC	PAIP1 →	+0.280	+0.306	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,172 associations by consensus.

TMEM106B vs NUDCD3 — LUAD

Explore this scatter interactively →