TMEM106B

Across TCGA pan-cancer cohorts, TMEM106B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TMEM106B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TMEM106B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEM106B is over-expressed in tumor, although a few such as UCEC and KIRC show the opposite, repressed pattern.

LUAD, UCEC, and BRCA are the cancer types where TMEM106B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEM106B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+1.283	<.001	9	view →
UCEC	All	All	−1.080	<.001	6	view →
BRCA	All	II,III,IV	+0.348	<.001	6	view →
LIHC	Male	All	+0.614	<.001	5	view →
KIRC	All	All	−0.231	.007	5	view →
CHOL	All	All	+1.034	.001	4	view →
KICH	All	All	−0.676	.002	4	view →
KIRP	All	II,III,IV	+0.580	.003	4	view →
PAAD	All	All	+0.514	.043	2	view →
STAD	All	All	+0.433	.044	2	view →
LUSC	All	All	+0.380	<.001	2	view →
PRAD	All	All	−0.326	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TMEM106B–LUAD

Open the LUAD breakdown →