TMEM106B

Across TCGA patient cohorts, TMEM106B protein abundance is significantly associated with the RNA expression of many other genes, with 10,764 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible TMEM106B-associated genes across cancer lineages are TSPAN13, PPP1R16B, and KDELR2. Each is linked with TMEM106B in more than 4 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM106B versus TSPAN13 in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TSPAN13 →	+1.032	+0.388	<.001	<.001	3	5
CCRCC	PPP1R16B →	-0.695	-0.267	<.001	<.001	3	4
HNSC	KDELR2 →	+0.782	+0.338	<.001	<.001	2	5
HNSC	FCRL3 →	-0.668	-0.242	<.001	<.001	3	4
HNSC	TNXB →	-0.983	-0.274	<.001	<.001	3	4
PDAC	P2RY8 →	-0.740	-0.459	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,764 associations by consensus.

TMEM106B vs TSPAN13 — BRCA

Explore this scatter interactively →