TMEM106B

Across TCGA patient cohorts, TMEM106B mutation is significantly associated with the RNA expression of many other genes, with 1,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM106B-associated genes across cancer lineages are MIR7702, MIR4445, and RNU6-39P. Each is linked with TMEM106B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7702 grouped by TMEM106B-low versus TMEM106B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.214	+4.153	<.001	.005	3	2
BRCA	MIR4445 →	+0.326	+7.731	<.001	.009	3	2
UCEC	RNU6-39P →	+0.347	+2.202	.001	.005	3	2
UCEC	RPL35AP30 →	+0.187	+2.033	.003	.003	3	2
UCEC	RPL35AP34 →	+0.542	+3.057	<.001	<.001	3	2
UCEC	RNA5SP419 →	+0.791	+2.202	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

MIR7702 by TMEM106B expression — UCEC

Explore this box plot interactively →