TMEM106B

Across TCGA patient cohorts, TMEM106B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEM106B-associated genes across cancer lineages are EGFR_pY1068, ACVRL1, and Ku80. Each is linked with TMEM106B in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TMEM106B-low versus TMEM106B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.290	-3.321	.027	.010	3	1
UCEC	ACVRL1 →	-0.161	-3.150	.024	.019	3	1
UCEC	Ku80 →	+0.281	+2.183	.023	.035	3	1
UCEC	MEK1 →	+0.394	+3.321	.040	.010	3	1
UCEC	Rab11 →	-0.194	-3.321	.010	.010	3	1
UCEC	Annexin_VII →	-0.148	-3.321	.041	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by TMEM106B expression — UCEC

Explore this box plot interactively →