TMEM106B

Across TCGA cell cohorts, TMEM106B RNA expression is significantly associated with the RNA expression of many other genes, with 10,080 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible TMEM106B-associated genes across cancer lineages are SNX13, AVL9, and VPS41. Each is linked with TMEM106B in more than 16 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMEM106B versus SNX13 in BLOOD_Myeloma, with a Pearson correlation of 0.74.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SNX13 →	+1.248	+1.388	<.001	<.001	3	17
LIVER	AVL9 →	+1.096	+1.454	<.001	<.001	3	16
BLOOD_Lymphoma	VPS41 →	+1.107	+1.173	<.001	.001	3	15
BONE	ELMOD2 →	+1.018	+1.279	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	UMAD1 →	+1.070	+1.002	<.001	<.001	2	15
UPPER_AERODIGESTIVE_TRACT	EIF2AK1 →	+0.863	+0.971	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,080 associations by consensus.

TMEM106B vs SNX13 — BLOOD_Myeloma

Explore this scatter interactively →