TMEM106B

Across TCGA cell cohorts, TMEM106B RNA expression is significantly associated with the go_rna of many other GO terms, with 3,803 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TMEM106B-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Macroautophagy, and Interleukin-10-mediated signaling pathway. Each is linked with TMEM106B in more than 14 cancer types. Because this analysis shows association rather than direction, both TMEM106B-to-partner and partner-to-TMEM106B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by TMEM106B-low versus TMEM106B-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM106B→partner) and Y-score (partner→TMEM106B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.074	+1.181	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.051	+0.678	.005	<.001	3	14
LUNG_SCLC	Interleukin-10-mediated signaling pathway →	+0.261	+0.907	<.001	<.001	3	13
STOMACH	Golgi vesicle transport →	+0.065	+0.918	.003	.002	2	14
KIDNEY	Process utilizing autophagic mechanism →	+0.060	+0.840	.008	.005	2	14
KIDNEY	Autophagy →	+0.060	+0.840	.008	.005	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,803 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by TMEM106B expression — CNS

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