TMEFF1

Across TCGA patient cohorts, TMEFF1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMEFF1-associated genes across cancer lineages are p90 RSK_pT359_S363, 14-3-3_beta, and EGFR_pY1068. Each is linked with TMEFF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEFF1-to-partner and partner-to-TMEFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK_pT359_S363 grouped by TMEFF1-low versus TMEFF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF1→partner) and Y-score (partner→TMEFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK_pT359_S363 →	-0.231	-2.449	.007	.019	3	2
UCEC	14-3-3_beta →	-0.120	-3.558	.004	.002	3	1
UCEC	EGFR_pY1068 →	-0.367	-3.584	<.001	.002	3	1
UCEC	eIF4G →	+0.388	+3.169	.003	.018	3	1
UCEC	A-Raf_pS299 →	-0.216	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.230	+2.222	.004	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

p90 RSK_pT359_S363 by TMEFF1 expression — UCEC

Explore this box plot interactively →