TMEFF1

Across TCGA pan-cancer cohorts, TMEFF1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TMEFF1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TMEFF1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMEFF1 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, THCA, and UCEC are the cancer types where TMEFF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMEFF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.232	<.001	12	view →
THCA	All	All	−0.236	.001	7	view →
UCEC	All	All	+0.579	.001	6	view →
LUAD	All	All	+0.186	<.001	6	view →
LUSC	All	All	+0.333	<.001	5	view →
COAD	All	II,III,IV	−0.025	.005	5	view →
BRCA	All	II,III,IV	+0.089	<.001	4	view →
KIRC	Male	II,III,IV	−0.050	<.001	4	view →
KIRP	All	All	+0.137	.025	2	view →
READ	Female	All	−0.115	.010	2	view →
CHOL	All	All	+0.078	.031	1	view →
STAD	Male	IV	−0.065	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TMEFF1–HNSC

Open the HNSC breakdown →