TMEFF1

Across TCGA cell cohorts, TMEFF1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEFF1-associated genes across cancer lineages are OR10W1, LCE1F, and SERPINA10. Each is linked with TMEFF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEFF1-to-partner and partner-to-TMEFF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by TMEFF1-low versus TMEFF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEFF1→partner) and Y-score (partner→TMEFF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	LCE1F →	+0.165	+5.415	<.001	.004	3	1
BLOOD_Leukemia	SERPINA10 →	+0.123	+3.912	<.001	.006	3	1
BLOOD_Leukemia	CRYAA →	+0.088	+3.705	<.001	.007	3	1
BLOOD_Leukemia	HSD3B2 →	+0.049	+4.339	<.001	.002	3	1
BLOOD_Leukemia	HTR2C →	+0.389	+3.712	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR10W1 by TMEFF1 expression — LARGE_INTESTINE

Explore this box plot interactively →