TMED4

Across TCGA patient cohorts, TMED4 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,985 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMED4-associated proteins across cancer lineages are NUDCD3, PURB, and SUN1. Each is linked with TMED4 in more than 8 cancer types. Because this analysis shows association rather than direction, both TMED4-to-partner and partner-to-TMED4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMED4 versus NUDCD3 in BRCA, with a Pearson correlation of 0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED4→partner) and Y-score (partner→TMED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUDCD3 →	+0.411	+0.423	<.001	<.001	3	9
HNSC	PURB →	+0.375	+0.543	<.001	.003	3	7
LUAD	SUN1 →	+0.362	+0.444	<.001	<.001	3	6
LUAD	BAG6 →	+0.223	+0.392	<.001	<.001	3	6
HNSC	ZNF316_S112 →	+0.482	+0.630	<.001	<.001	3	5
UCEC	ZKSCAN1 →	+0.307	+0.447	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,985 associations by consensus.

TMED4 vs NUDCD3 — BRCA

Explore this scatter interactively →