TMED4

Across TCGA pan-cancer cohorts, TMED4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TMED4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMED4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TMED4 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where TMED4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMED4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+0.793	<.001	11	view →
HNSC	Male	III,IV	+0.766	<.001	11	view →
BLCA	All	III,IV	+0.717	<.001	10	view →
LIHC	Female	II,III,IV	+0.977	<.001	9	view →
LUAD	Male	III,IV	+0.861	<.001	9	view →
BRCA	All	III,IV	+0.590	<.001	8	view →
THCA	Male	III,IV	−0.582	.002	8	view →
KIRC	All	All	+0.190	.001	6	view →
CHOL	Female	All	+1.656	<.001	5	view →
STAD	All	II,III,IV	+0.612	<.001	4	view →
PAAD	All	All	+0.572	.003	4	view →
READ	All	All	+0.436	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TMED4–COAD

Open the COAD breakdown →