TMED4

Across TCGA patient cohorts, TMED4 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED4-associated genes across cancer lineages are RNA5SP369, RN7SL478P, and RN7SKP96. Each is linked with TMED4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMED4-to-partner and partner-to-TMED4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by TMED4-low versus TMED4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED4→partner) and Y-score (partner→TMED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.891	+3.778	<.001	.007	3	3
BLCA	RN7SL478P →	+0.195	+3.683	.006	.003	3	3
BLCA	RN7SKP96 →	+0.272	+3.867	.001	.004	3	2
UCEC	RNA5SP516 →	+0.524	+4.352	<.001	.008	3	2
UCEC	RNU7-29P →	+0.576	+5.137	<.001	.003	3	2
UCEC	SNRPGP17 →	+0.456	+3.879	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

RNA5SP369 by TMED4 expression — UCEC

Explore this box plot interactively →