TMED4

Across TCGA cell cohorts, TMED4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,751 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMED4-associated GO terms across cancer lineages are ER-nucleus signaling pathway, Golgi vesicle transport, and Endosomal transport. Each is linked with TMED4 in more than 11 cancer types. Because this analysis shows association rather than direction, both TMED4-to-partner and partner-to-TMED4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-nucleus signaling pathway grouped by TMED4-low versus TMED4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED4→partner) and Y-score (partner→TMED4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ER-nucleus signaling pathway →	+0.112	+0.759	<.001	.004	3	12
OESOPHAGUS	Golgi vesicle transport →	+0.082	+0.875	.004	.002	3	12
KIDNEY	Endosomal transport →	+0.046	+0.784	.001	<.001	3	11
PANCREAS	Endoplasmic reticulum unfolded protein response →	+0.092	+0.555	.001	.004	3	11
PANCREAS	Process utilizing autophagic mechanism →	+0.034	+0.432	.002	.004	3	11
STOMACH	Protein targeting →	+0.079	+0.774	.007	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,751 associations by consensus.

ER-nucleus signaling pathway by TMED4 expression — UPPER_AERODIGESTIVE_TRACT

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