TMED10

Across TCGA patient cohorts, TMED10 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMED10-associated genes across cancer lineages are Gab2, ACVRL1, and Lck. Each is linked with TMED10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMED10-to-partner and partner-to-TMED10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TMED10-low versus TMED10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMED10→partner) and Y-score (partner→TMED10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.365	+3.000	.034	.036	3	1
UCEC	ACVRL1 →	-0.190	-3.584	.003	.002	3	1
UCEC	Lck →	-0.231	-3.000	.017	.036	3	1
UCEC	LKB1 →	-0.111	-2.459	.030	.020	3	1
UCEC	Paxillin →	+0.331	+3.179	.008	.010	3	1
UCEC	Tuberin →	+0.514	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Gab2 by TMED10 expression — UCEC

Explore this box plot interactively →