TMCO5A

Across TCGA patient cohorts, TMCO5A mutation is significantly associated with the RNA expression of many other genes, with 2,593 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO5A-associated genes across cancer lineages are NACAP6, BUD31P1, and PHF7. Each is linked with TMCO5A in more than 2 cancer types. Because this analysis shows association rather than direction, both TMCO5A-to-partner and partner-to-TMCO5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NACAP6 grouped by TMCO5A-low versus TMCO5A-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO5A→partner) and Y-score (partner→TMCO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NACAP6 →	+0.102	+4.655	<.001	.007	3	3
LUSC	BUD31P1 →	+0.221	+4.792	<.001	.006	3	3
SKCM	PHF7 →	+0.528	+2.757	.001	.003	3	2
SKCM	NDUFC1 →	+0.445	+2.706	<.001	.003	3	2
SKCM	ITGB1BP1 →	+0.675	+3.360	<.001	.004	3	2
SKCM	PLXNC1 →	+1.351	+2.706	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,593 associations by consensus.

NACAP6 by TMCO5A expression — HNSC

Explore this box plot interactively →