TMCO5A

Across TCGA patient cohorts, TMCO5A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO5A-associated genes across cancer lineages are ERK2, 4E-BP1, and 14-3-3_beta. Each is linked with TMCO5A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO5A-to-partner and partner-to-TMCO5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TMCO5A-low versus TMCO5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO5A→partner) and Y-score (partner→TMCO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.188	+1.502	.007	.030	3	2
UCEC	4E-BP1 →	+0.331	+2.837	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.091	-1.847	.013	.049	3	1
UCEC	EGFR_pY1068 →	-0.257	-1.847	.005	.008	3	1
UCEC	A-Raf_pS299 →	-0.130	-2.000	.003	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.174	-2.115	.004	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by TMCO5A expression — UCEC

Explore this box plot interactively →