TMCO5A

Across TCGA cell cohorts, TMCO5A mutation is significantly associated with the mutation status of many other genes, with 38 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TMCO5A-associated genes across cancer lineages are KIF5C, AHCYL1, and SDC2. Each is linked with TMCO5A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO5A-to-partner and partner-to-TMCO5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF5C grouped by TMCO5A-low versus TMCO5A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO5A→partner) and Y-score (partner→TMCO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KIF5C →	+4.772	+5.339	.004	.004	1	1
LUNG_NSCLC_LUAD	AHCYL1 →	+5.772	+5.772	.002	.002	1	1
LUNG_NSCLC_LUAD	SDC2 →	+4.772	+5.339	.004	.004	1	1
LUNG_NSCLC_LUAD	VAT1L →	+4.187	+5.000	.008	.008	1	1
LUNG_NSCLC_LUAD	TENT5D →	+4.187	+5.000	.008	.008	1	1
LUNG_NSCLC_LUAD	SLCO2A1 →	+4.187	+5.000	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

KIF5C by TMCO5A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →