TMCO4

Across TCGA patient cohorts, TMCO4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMCO4-associated genes across cancer lineages are YB-1, ERCC1, and SCD. Each is linked with TMCO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMCO4-to-partner and partner-to-TMCO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YB-1 grouped by TMCO4-low versus TMCO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO4→partner) and Y-score (partner→TMCO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YB-1 →	+0.182	+3.459	.003	.005	3	2
SKCM	ERCC1 →	+0.193	+2.339	.017	.019	3	1
SKCM	SCD →	+0.198	+3.459	.006	.005	3	1
UCEC	Notch1 →	+0.210	+3.598	<.001	.001	3	1
UCEC	Rad50 →	-0.223	-2.986	.019	.035	3	1
UCEC	Smad1 →	-0.143	-2.459	.020	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

YB-1 by TMCO4 expression — UCEC

Explore this box plot interactively →