TMCO4

Across TCGA pan-cancer cohorts, TMCO4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TMCO4 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TMCO4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMCO4 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRP show a favorable association.

MESO, KIRP, and LGG are the cancer types where TMCO4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.676	0.406	<.001	120	view →
KIRP	DFS	Tertile	All	0.854	0.606	.002	82	view →
LGG	OS	Median	All	0.328	0.545	<.001	53	view →
ACC	DFS	Median	All	0.281	0.614	<.001	48	view →
SCLC	DFS	Quartile	All	0.699	0.300	.001	39	view →
KIRC	OS	Tertile	All	0.749	0.528	<.001	30	view →
LAML	DFS	Quartile	All	0.446	0.696	.008	24	view →
GBM	DFS	Tertile	All	0.195	0.333	.010	23	view →
LIHC	OS	Quartile	All	0.613	0.790	.007	23	view →
SARC	OS	Median	All	0.887	0.787	.004	11	view →
LUSC	DFS	Tertile	II,III,IV	0.638	0.791	.010	11	view →
BLCA	DFS	Tertile	IV	0.528	0.193	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TMCO4–MESO (OS)

Open the MESO breakdown →