TMCO4

Across TCGA cell cohorts, TMCO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,915 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TMCO4-associated GO terms across cancer lineages are Negative regulation of actin filament polymerization, Actomyosin structure organization, and Intracellular receptor signaling pathway. Each is linked with TMCO4 in more than 10 cancer types. Because this analysis shows association rather than direction, both TMCO4-to-partner and partner-to-TMCO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament polymerization grouped by TMCO4-low versus TMCO4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMCO4→partner) and Y-score (partner→TMCO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of actin filament polymerization →	+0.155	+1.671	<.001	<.001	3	11
OESOPHAGUS	Actomyosin structure organization →	+0.097	+0.821	<.001	.005	3	11
BONE	Intracellular receptor signaling pathway →	+0.050	+1.855	<.001	.001	3	11
BONE	Regulation of protein localization to plasma membrane →	+0.141	+2.527	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of protein localization to cell periphery →	+0.095	+0.985	.001	.002	3	10
OVARY	Positive regulation of protein localization to cell periphery →	+0.087	+1.226	.005	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,915 associations by consensus.

Negative regulation of actin filament polymerization by TMCO4 expression — STOMACH

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